The body’s immune system helps keep tissues healthy and plays a role in repairing tissue that may have been affected by a person's health status or other factors (see table). The body employs a tailored immune response to resolve these countless challenges.1 The resolution activity includes recruiting immune cells, clearing cellular debris in affected tissues, resuming normal immune activity, and maintaining tissue health.*

Leading-edge science in the resolution of the immune response*

Groundbreaking research has discovered that specialized pro-resolving mediators (SPMs) are produced at the affected tissue site and function as “resolution agonists,” orchestrating activities to support resolution (i.e., completion) of the immune response and the return to the previous healthy condition.*2-4

If an individual is unable to produce needed levels of SPMs during an immune challenge—due to lifestyle behaviors, dietary choices, or health status—the resolution can be impacted.*3,5

OmegaGenics SPM Active: Targeted support for the immune response*

Since SPMs have been found to be critical for the resolution of the immune response, incorporating OmegaGenics SPM Active to supplementation protocols represents a more targeted nutritional approach to support the resolution of the immune response and tissue health.*3 OmegaGenics SPM Active is an exclusive, standardized SPM formula developed through advanced fractionation technology. Metagenics, in collaboration with world-renowned SPM experts, is the first to establish and set the standard for defining SPMs based on activity for use in nutraceutical products (ActiveIR). Active IR is a patent-pending technology exclusive to Metagenics that establishes a collective set of proprietary processes designed to isolate, measure, and verify the active SPMs 17-HDHA and 18-HEPE.

How are SPMs different from omega-3 fatty acids?

SPMs are structurally different from EPA and DHA(omega-3 fatty acids). Although our body can utilize EPA and DHA and other polyunsaturated fatty acids (PUFAs) to generate SPMs, there are many enzymatic steps involved in this biological process.2 Sometimes factors such as aging, health status, or a poor diet can interfere with sufficient production of SPMs in the body from polyunsaturated fatty acids (PUFAs).

SPMs are functionally different from EPA and DHA. SPMs have unique pro-resolving properties, whereas EPA and DHA have other health benefits (such as supporting memory, healthy triglyceride and cardiovascular health). Therefore, adding OmegaGenics
SPM Active provides a more targeted and direct support for the resolution of the immune response.*3

  1. Kumar V, Abbas AK, Aster A. Robbins Basic Pathology 9th ed. Saunders, 2012.
  2. Serhan CN. Nature. 2014;510:91-101.
  3. Spite M, Claria J, Serhan CN. Cell Metab. 2014;19:21-36.
  4. Recchiuti A. J Gerontol Geriat Res. 2014;3:151.
  5. Claria J, Nguyen BT, Madenci AL, Ozaki CK, Serhan CN. Am J Physiol Cell Physiol. 2012;304:C1141-49.


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SPM Active®

Specialized Pro-resolving Mediators

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